Mitochondria-targeted tetrapeptide

SS-31.

A synthetic four-amino-acid peptide from the Szeto-Schiller series, also known as elamipretide. Binds cardiolipin on the inner mitochondrial membrane in published research models.

Key Information

CompoundSS-31
Research categoryLongevity Research
Available sizes10mg, 50mg
PricingFrom £30
FormatLyophilised powder in sealed vial
Purity>99% by HPLC (Janoshik Analytical, batch-verified)
Intended useIn-vitro laboratory research only. Not for human consumption.

Chemical & Reference Data

Reference data drawn from public databases (PubChem, UniProt) and peer-reviewed literature. For research and laboratory characterisation only.

Compound classSynthetic mitochondria-targeted tetrapeptide (Szeto-Schiller series)
Molecular formulaC32H49N9O5
Molecular weight639.8 g/mol
CAS Registry Number736992-21-5
Number of residues4
Amino acid sequenceD-Arg-Dmt-Lys-Phe-NH2
Receptor / mechanismBinds cardiolipin on the inner mitochondrial membrane; not a classical receptor agonist.
Reported half-lifeShort plasma half-life reported in published pharmacokinetic studies.
SolubilityLyophilised powder reconstitutes in bacteriostatic water for laboratory use.
Storage (lyophilised)Stable at 2–8 °C lyophilised for 18+ months.
Storage (reconstituted)Reconstituted: store at 2–8 °C, use within 14 days.
Clinical / regulatory statusInvestigational; studied in registered clinical trials as elamipretide.

Research Profile

  • Mitochondria-targeted tetrapeptide
  • Four-amino-acid sequence (D-Arg-Dmt-Lys-Phe-NH2)
  • Studied for cardiolipin binding and mitochondrial bioenergetics
  • Third-party purity tested
  • Research use only

SS-31, also known as elamipretide, is a synthetic four-amino-acid peptide from the Szeto-Schiller series. It is characterised in the literature as binding cardiolipin on the inner mitochondrial membrane, and has been studied for its effects on electron transport and mitochondrial bioenergetics in cellular and preclinical models. It has also been investigated in registered clinical trials under the name elamipretide. Supplied as lyophilised powder for in-vitro research use only.

The above describes how this compound is characterised in the published peer-reviewed literature. It is not a claim about effects in humans.

Laboratory Handling

SS-31 is supplied as a lyophilised (freeze-dried) powder in a sealed glass vial. For laboratory reconstitution, add the desired volume of diluent (typically bacteriostatic water) slowly down the side wall of the vial. Swirl gently until fully dissolved - do not vortex or shake. Store reconstituted solutions at 2–8 °C and use within 4–6 weeks.

Use our Reconstitution Volume Calculator to compute the resulting mg/ml concentration.

StateTemperatureShelf life
Lyophilised2–8 °C or −20 °CUp to 24 months
Reconstituted2–8 °C4–6 weeks typical

Purity & Verification

Every batch of SS-31 we supply is independently HPLC-verified by Janoshik Analytical. Where a Janoshik report has been issued for the current batch it is supplied with the order and carries a unique verification key that can be authenticated against Janoshik's records. Reported purity is consistently above 99%.

Related Compounds

Researchers working with SS-31 often work alongside the following compounds in the preclinical literature:

  • SS-31 - Longevity Research
  • NAD+ - Longevity Research